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Concerning the role of endogenous copper in the acute inflammatory process.

Authors
  • Milanino, R
  • Conforti, A
  • Fracasso, M E
  • Franco, L
  • Leone, R
  • Passarella, E
  • Tarter, G
  • Velo, G P
Type
Published Article
Journal
Agents and Actions
Publisher
Springer-Verlag
Publication Date
Dec 01, 1979
Volume
9
Issue
5-6
Pages
581–588
Identifiers
PMID: 546181
Source
Medline
License
Unknown

Abstract

The development of two models of acute inflammation (carrageenan-induced foot oedema and pleurisy) was studied in rats after 1 month of a 0.2 p.p.m. copper-deficient diet and after 5 months of a 0.6-0.8 p.p.m. copper-deficient diet. A 'pro-inflammatory' effect of copper deficiency was observed with the 0.2 p.p.m. diet, whilst no effect was evident following the 0.6-0.8 p.p.m. copper deficient diet. These results are briefly commented upon.

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