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Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

Authors
  • Rocha, Cecilia Constantino1
  • da Silveira, Juliano Coelho2
  • Forde, Niamh3
  • Binelli, Mario4
  • Pugliesi, Guilherme1
  • 1 Departamento de Reprodução Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Pirassununga, SP, Brasil
  • 2 Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, SP, Brasil
  • 3 Discovery and Translational Sciences Department, School of Medicine, University of Leeds, Leeds, Yorkshire, United Kingdom
  • 4 Department of Animal Sciences, University of Florida, Gainesville, FL, USA
Type
Published Article
Journal
Animal Reproduction
Publisher
Colégio Brasileiro de Reprodução Animal
Publication Date
May 10, 2021
Volume
18
Issue
1
Identifiers
DOI: 10.1590/1984-3143-AR2020-0048
PMID: 34122650
PMCID: PMC8189353
Source
PubMed Central
Keywords
Disciplines
  • Review Article
License
Unknown

Abstract

This review focuses on the innate immune events modulated by conceptus signaling during early pregnancy in ruminants. Interferon-tau (IFN-τ) plays a role in the recognition of pregnancy in ruminants, which involves more than the inhibition of luteolytic pulses of PGF2α to maintain corpus luteum function. For successful pregnancy establishment, the allogenic conceptus needs to prevent rejection by the female. Therefore, IFN-τ exerts paracrine and endocrine actions to regulate the innate immune system and prevent conceptus rejection. Additionally, other immune regulators work in parallel with IFN-τ, such as the pattern recognition receptors (PRR). These receptors are activated during viral and bacterial infections and in early pregnancy, but it remains unknown whether PPR expression and function are controlled by IFN-τ. Therefore, this review focuses on the main components of the innate immune response that are involved with early pregnancy and their importance to avoid conceptus rejection.

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