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Concentrations of metronidazole and tinidazole in abdominal tissues after a single intravenous infusion and repetitive oral administration.

Authors
  • Viitanen, J
  • Auvinen, O
  • Tunturi, T
  • Männistö, P
  • Haataja, H
Type
Published Article
Journal
Chemotherapy
Publication Date
Jan 01, 1984
Volume
30
Issue
4
Pages
211–215
Identifiers
PMID: 6744973
Source
Medline
License
Unknown

Abstract

Concentrations of metronidazole and tinidazole in serum and abdominal tissues were determined after a single 500-mg intravenous infusion or after a 5-day oral dosage of 500 mg three times daily in groups of 10 patients each. In the patients who got the single infusions, the concentrations in tissues (except fat) reached almost the serum levels 10 min after the infusion. At 24 h, the tinidazole concentrations in serum averaged 3.2 micrograms/ml and those of metronidazole 1.3 micrograms/ml. In the patients who got the 5-day oral dosages, the steady-state levels of tinidazole in both serum and tissues were twice as high as those of metronidazole.

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