Sand-water slurry was investigated on an experimental pipe loop of inner diameter D = 100 mm with the horizontal, inclined, and vertical smooth pipe sections. A narrow particle size distribution silica sand of mean diameter 0.87 mm was used. The experimental investigation focused on the effects of pipe inclination, overall slurry concentration, and mean velocity on concentration distribution and deposition limit velocity. The measured concentration profiles showed different degrees of stratification for the positive and negative pipe inclinations. The degree of stratification depended on the pipe inclination and on overall slurry concentration and velocity. The ascending flow was less stratified than the corresponding descending flow, the difference increasing from horizontal flow up to an inclination angle of about +30°. The deposition limit velocity was sensitive to the pipe inclination, reaching higher values in the ascending than in the horizontal pipe. The maximum deposition limit value was reached for an inclination angle of about +25°, and the limit remained practically constant in value, about 1.25 times higher than that in the horizontal pipe. Conversely, in the descending pipe, the deposition limit decreased significantly with the negative slopes and tended to be zero for an inclination angle of about −30°, where no stationary bed was observed.