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Computer System “Gene Discovery” to Search for Patterns in Eukaryotic Regulatory Nucleotide Sequences

Authors
  • Vityaev, E. E.
  • Orlov, Yu. L.
  • Vishnevsky, O. V.
  • Belenok, A. S.
  • Kolchanov, N. A.
Type
Published Article
Journal
Molecular Biology
Publisher
Pleiades Publishing
Publication Date
Nov 01, 2001
Volume
35
Issue
6
Pages
810–817
Identifiers
DOI: 10.1023/A:1013273932056
Source
Springer Nature
Keywords
License
Yellow

Abstract

A method is proposed to automatically search for patterns in the mutual location of context signals in regulatory DNA sequences. The procedure is based on the methods of Data Mining and Knowledge Discovery software, implemented in a computer system Gene Discovery. This system was used to study erythroid-specific promoters and promoters of the endocrine-system genes from TRRD. We detected some trends in occurrence and localization of specific oligonucleotide groups.

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