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Computational modeling reveals molecular details of epidermal growth factor binding.

Authors
  • Mayawala, Kapil
  • Vlachos, Dionisios G
  • Edwards, Jeremy S
Type
Published Article
Journal
BMC Cell Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2005
Volume
6
Pages
41–41
Identifiers
PMID: 16318625
Source
Medline
License
Unknown

Abstract

Our computer simulations reveal the mechanism of EGF binding on EGFR. Overall, we show that spatial simulation of receptor dynamics can be used to gain a mechanistic understanding of receptor activation which may in turn enable improved cancer treatments in the future.

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