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Computational fluid dynamics simulation of airflow in the trachea and main bronchi for the subjects with left pulmonary artery sling

Authors
  • Qi, Shouliang1, 2
  • Li, Zhenghua1, 2
  • Yue, Yong3
  • van Triest, Han JW1, 2
  • Kang, Yan1, 2
  • 1 Northeastern University, Sino-Dutch Biomedical and Information Engineering School, Shenyang, China , Shenyang (China)
  • 2 Northeastern University, Key Laboratory of Medical Imaging Computing (Ministry of Education), Shenyang, China , Shenyang (China)
  • 3 Shengjing Hospital of China Medical University, Department of Radiology, Shenyang, China , Shenyang (China)
Type
Published Article
Journal
BioMedical Engineering OnLine
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 24, 2014
Volume
13
Issue
1
Identifiers
DOI: 10.1186/1475-925X-13-85
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundLeft pulmonary artery sling (LPAS) is a rare but severe congenital anomaly, in which the stenoses are formed in the trachea and/or main bronchi. Multi-detector computed tomography (MDCT) provides useful anatomical images, but does not offer functional information. The objective of the present study is to quantitatively analyze the airflow in the trachea and main bronchi of LPAS subjects through computational fluid dynamics (CFD) simulation.MethodsFive subjects (four LPAS patients, one normal control) aging 6-19 months are analyzed. The geometric model of the trachea and the two main bronchi is extracted from the MDCT images. The inlet velocity is determined based on the body weight and the inlet area. Both the geometric model and personalized inflow conditions are imported into CFD software, ANSYS. The pressure drop, mass flow ratio through two bronchi, wall pressure, flow velocity and wall shear stress (WSS) are obtained, and compared to the normal control.ResultsDue to the tracheal and/or bronchial stenosis, the pressure drop for the LPAS patients ranges 78.9 - 914.5 Pa, much higher than for the normal control (0.7 Pa). The mass flow ratio through the two bronchi does not correlate with the sectional area ratio if the anomalous left pulmonary artery compresses the trachea or bronchi. It is suggested that the C-shaped trachea plays an important role on facilitating the air flow into the left bronchus with the inertia force. For LPAS subjects, the distributions of velocities, wall pressure and WSS are less regular than for the normal control. At the stenotic site, high velocity, low wall pressure and high WSS are observed.ConclusionsUsing geometric models extracted from CT images and the patient-specified inlet boundary conditions, CFD simulation can provide vital quantitative flow information for LPAS. Due to the stenosis, high pressure drops, inconsistent distributions of velocities, wall pressure and WSS are observed. The C-shaped trachea may facilitate a larger flow of air into the left bronchus under the inertial force, and decrease the ventilation of the right lung. Quantitative and personalized information may help understand the mechanism of LPAS and the correlations between stenosis and dyspnea, and facilitate the structural and functional assessment of LPAS.

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