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Computational analysis of blood clot dissolution using a vibrating catheter tip.

Authors
  • Lee, Jeong Hyun
  • Oh, Jin Sun
  • Yoon, Bye Ri
  • Choi, Seung Hong
  • Rhee, Kyehan
  • Jho, Jae Young
  • Han, Moon Hee
Type
Published Article
Journal
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Publication Date
Apr 01, 2012
Volume
226
Issue
4
Pages
337–340
Identifiers
PMID: 22611874
Source
Medline
License
Unknown

Abstract

We developed a novel concept of endovascular thrombolysis that employs a vibrating electroactive polymer actuator. In order to predict the efficacy of thrombolysis using the developed vibrating actuator, enzyme (plasminogen activator) perfusion into a clot was analyzed by solving flow fields and species transport equations considering the fluid structure interaction. In vitro thrombolysis experiments were also performed. Computational results showed that plasminogen activator perfusion into a clot was enhanced by actuator vibration at frequencies of 1 and 5 Hz. Plasminogen activator perfusion was affected by the actuator oscillation frequencies and amplitudes that were determined by electromechanical characteristics of a polymer actuator. Computed plasminogen activator perfused volumes were compared with experimentally measured dissolved clot volumes. The computed plasminogen activator perfusion volumes with threshold concentrations of 16% of the initial plasminogen activator concentration agreed well with the in vitro experimental data. This study showed the effectiveness of actuator oscillation on thrombolysis and the validity of the computational plasminogen activator perfusion model for predicting thrombolysis in complex flow fields induced by an oscillating actuator.

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