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Comprehensive In Vitro Study of the Flow Past Two Transcatheter Aortic Valves: Comparison with a Severe Stenotic Case.

Authors
  • Corso, Pascal1
  • Gülan, Utku2
  • Cohrs, Nicholas3
  • Stark, Wendelin Jan3
  • Duru, Firat4
  • Holzner, Markus2
  • 1 Institute for Environmental Engineering, Swiss Institute of Technology in Zurich, Zurich, Switzerland. [email protected] , (Switzerland)
  • 2 Institute for Environmental Engineering, Swiss Institute of Technology in Zurich, Zurich, Switzerland. , (Switzerland)
  • 3 Functional Materials Laboratory, Swiss Institute of Technology in Zurich, Zurich, Switzerland. , (Switzerland)
  • 4 Department of Cardiology, University Heart Center, Zurich, Switzerland. , (Switzerland)
Type
Published Article
Journal
Annals of Biomedical Engineering
Publisher
Springer-Verlag
Publication Date
Nov 01, 2019
Volume
47
Issue
11
Pages
2241–2257
Identifiers
DOI: 10.1007/s10439-019-02289-y
PMID: 31111327
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We investigate the flow past two transcatheter aortic valves (TAVs) and one severely calcified valve in an anatomically realistic aorta geometry to evaluate the ability of the TAVs to establish a healthier aortic flow compared to a diseased case. Velocity measurements of pulsatile flow are carried out using the 3D-particle tracking velocimetry technique. We present a novel approach based on the Smagorinsky model to assess the important subvoxel-scale (here smaller than 750 [Formula: see text]m) shear stress contribution that is usually unavailable in experiments. Both TAV models feature a small retrograde flow of about 5% of the stroke volume and a lower number of coherent vortical structures. Turbulence past the TAVs is strongly suppressed as evidenced by the lower levels of turbulent kinetic energy even though the newer generation TAV performs better than the old one. Also lysis indices are substantially reduced in both models. The new generation TAV displays a slightly higher risk for thrombogenicity due to longer exposure times. We anticipate that our new approach to include turbulence and shear stress related quantities may help to validate the design of cardiovascular devices.

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