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A Comprehensive Understanding of Dietary Effects on C. elegans Physiology

Authors
  • Zhou, Jie-jun1
  • Chun, Lei1
  • Liu, Jian-feng1
  • 1 Huazhong University of Science and Technology, Collaborative Innovation Center for Brain Science, College of Life Science and Technology, Wuhan, 430074, China , Wuhan (China)
Type
Published Article
Journal
Current Medical Science
Publisher
Huazhong University of Science and Technology
Publication Date
Oct 14, 2019
Volume
39
Issue
5
Pages
679–684
Identifiers
DOI: 10.1007/s11596-019-2091-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

Diet has been shown to play an important role in human physiology. It is a predominant exogenous factor regulating the composition of gut microbiota, and dietary intervention holds promise for treatment of diseases such as obesity, type 2 diabetes, and malnutrition. Furthermore, it was reported that diet has significant effects on physiological processes of C. elegans, including reproduction, fat storage, and aging. To reveal novel signaling pathways responsive to different diets, C. elegans and its bacterial diet were used as an interspecies model system to mimic the interaction between host and gut microbiota. Most signaling pathways identified in C. elegans are highly conserved across different species, including humans. A better understanding of these pathways can, therefore, help to develop interventions for human diseases. In this article, we summarize recent achievements on molecular mechanisms underlying the response of C. elegans to different diets and discuss their relevance to human health.

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