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A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives.

Authors
  • Khandelwal, Rahul1
  • Vagha, Jayant D1
  • Meshram, Revat J1
  • Patel, Ankita1
  • 1 Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Type
Published Article
Journal
Cureus
Publisher
Cureus, Inc.
Publication Date
Mar 01, 2024
Volume
16
Issue
3
Identifiers
DOI: 10.7759/cureus.56755
PMID: 38650769
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Digoxin, a cardiac glycoside derived from the foxglove plant (Digitalis spp.), has been utilized for centuries in managing various cardiac conditions due to its ability to increase myocardial contractility and regulate heart rate. This comprehensive review explores the historical context, pharmacological properties, clinical applications, efficacy, safety profile, challenges, and future perspectives of digoxin. Tracing its journey from traditional medicine to modern cardiovascular therapeutics, we delve into its mechanism of action, therapeutic indications, and clinical guidelines. While digoxin remains a cornerstone therapy for heart failure and atrial fibrillation, its narrow therapeutic index and individual variability in response pose challenges in clinical practice. Nevertheless, ongoing research efforts aim to elucidate its role in emerging therapeutic areas and technological advancements in drug delivery. Despite the advent of newer pharmacological agents, digoxin's enduring relevance lies in its established efficacy, affordability, and global accessibility. This review underscores the symbiotic relationship between tradition and progress in cardiovascular medicine, highlighting the timeless pursuit of medical innovation to optimize patient care. Copyright © 2024, Khandelwal et al.

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