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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

Authors
  • Nakayasu, Ernesto S.1, 2
  • Syed, Farooq3, 2
  • Tersey, Sarah A.3, 4
  • Gritsenko, Marina A.1
  • Mitchell, Hugh D.1
  • Chan, Chi Yuet1
  • Dirice, Ercument5
  • Turatsinze, Jean-Valery6
  • Cui, Yi7, 8
  • Kulkarni, Rohit N.5
  • Eizirik, Decio L.6
  • Qian, Wei-Jun1
  • Webb-Robertson, Bobbie-Jo M.1, 9
  • Evans-Molina, Carmella3
  • Mirmira, Raghavendra G.3, 4, 10
  • Metz, Thomas O.1, 10, 11
  • 1 Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
  • 2 These authors contributed equally
  • 3 Center for Diabetes and Metabolic Diseases and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
  • 4 Present address: Kovler Diabetes Center and Department of Medicine, University of Chicago, Chicago, IL, USA
  • 5 Department of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women’s Hospital, and Harvard Stem Cell Institute, Boston, MA, USA
  • 6 ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium
  • 7 Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA
  • 8 Present address: Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
  • 9 Computing and Analytics Division, Pacific Northwest National Laboratory, Richland, WA, USA
  • 10 Senior author
  • 11 Lead Contact
Type
Published Article
Journal
Cell metabolism
Publication Date
Jan 09, 2020
Volume
31
Issue
2
Pages
363–374
Identifiers
DOI: 10.1016/j.cmet.2019.12.005
PMID: 31928885
PMCID: PMC7319177
Source
PubMed Central
License
Unknown

Abstract

Nakayasu et al. used a proteomics-based approach in human islets to study the T1D-related process of β-cell destruction. They found that pro-inflammatory cytokines lead to the suppression of GDF15 mRNA translation. The study also revealed that GDF15 promotes the protection of β cells and prevents diabetes onset in mice.

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