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A Comprehensive Outlook of Synthetic Strategies and Applications of Redox-Responsive Nanogels in Drug Delivery.

Authors
  • Kumar, Parveen1
  • Liu, Bo1
  • Behl, Gautam2
  • 1 Laboratory of Functional Molecules and Materials School of Physics and Optoelectronic Engineering, Shandong University of Technology, Xincun West Road 266, Zibo, 255000, China. , (China)
  • 2 Pharmaceutical and Molecular Biotechnology Research Centre, Department of Science, Waterford Institute of Technology, Cork Road, Waterford, X91K0EK, Republic of Ireland. , (Ireland)
Type
Published Article
Journal
Macromolecular bioscience
Publication Date
Aug 01, 2019
Volume
19
Issue
8
Identifiers
DOI: 10.1002/mabi.201900071
PMID: 31298803
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox-responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel-based drug delivery carriers utilizing redox-responsive cross-linkers bearing a variety of functional groups via various synthetic strategies. Redox-responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox-responsive nanogels. The present review provides an insight into the design and fabrication of redox-responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox-responsive cross-linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli-responsive nanogels is also discussed. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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