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A comprehensive meta-analysis of stem cell therapy for chronic angina.

Authors
  • Shah, Rahman1
  • Latham, Samuel B1
  • Khan, Sajjad A2
  • Shahreyar, Muhammad1
  • Hwang, Inyong1
  • Jovin, Ion S3
  • 1 Department of Internal Medicine, University of Tennessee, Memphis, Tennessee.
  • 2 Department of Internal Medicine, Aga Khan University, Karachi, Pakistan. , (Pakistan)
  • 3 Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
Type
Published Article
Journal
Clinical cardiology
Publication Date
Apr 01, 2018
Volume
41
Issue
4
Pages
525–531
Identifiers
DOI: 10.1002/clc.22922
PMID: 29664162
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A substantial proportion of patients with coronary artery disease do not achieve complete revascularization and continue to experience refractory angina despite optimal medical therapy. Recently, stem cell therapy has emerged as a potential therapeutic option for these patients. However, findings of individual trials have been scrutinized because of their small sample sizes and lack of statistical power. Therefore, we conducted an updated comprehensive meta-analysis of available randomized controlled trials (RCTs) with the largest sample size ever reported on this subject. In patients with chronic angina stem cell therapy improves clinical outcomes. Scientific databases and websites were searched for RCTs. Data were independently collected by 2 investigators, and disagreements were resolved by consensus. Data from 10 trials including 658 patients were analyzed. Stem cell therapy improved Canadian Cardiovascular Society angina class (risk ratio: 1.53, 95% CI: 1.09 to 2.15, P = 0.013), exercise capacity (standardized mean difference [SMD]: 0.56, 95% CI: 0.23 to 0.88, P = 0.001), and left ventricular ejection fraction (SMD: 0.63, 95% CI: 0.27 to 1.00, P = 0.001) compared with placebo. It also decreased anginal episodes (SMD: -1.21, 95% CI: -2.40 to -0.02, P = 0.045) and myocardial perfusion defects (SMD: -0.70, 95% CI: -1.11 to -0.29, P = 0.001). However, no improvements in all-cause mortality were observed after a relatively short follow-up. In patients with chronic angina on optimal medical therapy, stem cell therapy improves symptoms, exercise capacity, and left ventricular ejection fraction. These findings warrant confirmation using larger trials. © 2018 Wiley Periodicals, Inc.

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