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Composition of the immunoglobulin G glycome associates with the severity of COVID-19

Authors
  • Petrović, Tea1
  • Alves, Inês2, 3, 4
  • Bugada, Dario5, 6
  • Pascual, Julio7
  • Vučković, Frano1
  • Skelin, Andrea1
  • Gaifem, Joana2, 3
  • Villar-Garcia, Judit7
  • Vicente, Manuel M2, 3, 8
  • Fernandes, Ângela2, 3
  • Dias, Ana M2, 3
  • Kurolt, Ivan-Christian9
  • Markotić, Alemka9
  • Primorac, Dragan10, 11, 12, 13, 14, 15
  • Soares, Adriana16
  • Malheiro, Luis4, 17
  • Trbojević-Akmačić, Irena1
  • Abreu, Miguel8, 17
  • Sarmento e Castro, Rui8, 17
  • Bettinelli, Silvia18
  • And 10 more
  • 1 Genos Glycoscience Research Laboratory, Croatia , (Croatia)
  • 2 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Portugal , (Portugal)
  • 3 Institute for Research and Innovation in Health (I3S), Portugal , (Portugal)
  • 4 Medical Faculty, Portugal , (Portugal)
  • 5 Emergency and Intensive Care Department, Italy , (Italy)
  • 6 Italian Pain Group, Italy , (Italy)
  • 7 Hospital del Mar Medical Research Institute (IMIM), Spain , (Spain)
  • 8 Institute of Biomedical Sciences of Abel Salazar, Portugal , (Portugal)
  • 9 University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, Croatia , (Croatia)
  • 10 St. Catharine Hospital, Croatia , (Croatia)
  • 11 Eberly College of Science
  • 12 University of Split School of Medicine, Croatia , (Croatia)
  • 13 University of Osijek School of Medicine, Croatia , (Croatia)
  • 14 University of Osijek Faculty of Dental Medicine and Health, Croatia , (Croatia)
  • 15 Medical School REGIOMED, Germany , (Germany)
  • 16 Internal Medicine Department, Portugal , (Portugal)
  • 17 Infectious Diseases Department, Portugal , (Portugal)
  • 18 Biobank Unit, Italy , (Italy)
  • 19 Pain Service, Italy , (Italy)
  • 20 University of Zagreb Faculty of Pharmacy and Biochemistry, Croatia , (Croatia)
Type
Published Article
Journal
Glycobiology
Publisher
Oxford University Press
Publication Date
Nov 10, 2020
Identifiers
DOI: 10.1093/glycob/cwaa102
PMID: 33174592
PMCID: PMC7717252
Source
PubMed Central
Keywords
License
Unknown

Abstract

A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics. The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far. Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19. The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome. The most notable difference was the decrease in bisecting N -acetylglucosamine (GlcNAc) in severe patients from all three cohorts. IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing.

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