AIDS treatment regimens are so complex that it is nearly impossible for many patients to comply with them. The European AIDS Treatment Group (EATG) has produced a videotape to define the challenge of following combination therapies with protease inhibitors. Patients on an aggressive treatment program face daily pill counts of 30 or more, making compliance, and the resistance that develops with non-compliance, a major concern among health care providers. A Dutch study showed that 70 percent of those polled identify misunderstandings of available treatments as a major obstacle to compliance. The same survey showed that 50 percent of pharmacists and 35 percent of general practitioners cannot interpret and explain the requirements of antiretroviral treatments. EATG is calling for drug manufacturers to use technologies such as oral time release, transdermal devices, and implants to help patients adhere to treatment schedules. Practical guidelines also need to be developed to assist patients in remaining compliant.