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Complex Regional Pain Syndrome after severe COVID-19 - a case report.

Authors
  • Vaz, Ana1
  • Costa, Andreia2, 3
  • Pinto, André4, 3
  • Silva, Ana Isabel1
  • Figueiredo, Paulo4, 3
  • Sarmento, António4, 3
  • Santos, Lurdes4, 3
  • 1 Physical Medicine and Rehabilitation Department, Centro Hospitalar Universitário de São João, Porto, Portugal. , (Portugal)
  • 2 Neurology Department, Centro Hospitalar Universitário de São João, Porto, Portugal. , (Portugal)
  • 3 Faculty of Medicine, University of Porto, Portugal. , (Portugal)
  • 4 Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal. , (Portugal)
Type
Published Article
Journal
Heliyon
Publisher
Elsevier
Publication Date
Nov 24, 2021
Identifiers
DOI: 10.1016/j.heliyon.2021.e08462
PMID: 34841099
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neurological complications are frequently reported in an intensive care unit (ICU), as a manifestation of a critical systemic illness or of its treatment. On the specific setting of COVID-19 patients, peripheral nerve lesions can have a multiplicity of causes, such as post-infectious neuropathy, positioning-related neuropathy or iatrogeny. An unusual but potentially disabling complication of any peripheral nerve lesion is Complex Regional Pain Syndrome (CRPS). Although there have been no mechanistic studies assessing how SARS-CoV-2 might directly impact nociception, it is hypothesized that the systemic hyperinflammation seen in severe COVID-19 may contribute to peripheral and central neuronal sensitization, possibly increasing the risk of developing CRPS. This case report highlights the potential hazards and consequences of peripheral nerve injuries on an ICU setting in COVID-19 patients, as well as the importance of a multidisciplinary approach for an early diagnosis and treatment, which are directly related to a better prognosis. © 2021 The Author(s). Published by Elsevier Ltd.

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