Affordable Access

deepdyve-link
Publisher Website

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Authors
  • Noll, Kelsey E.1
  • Whitmore, Alan C.2
  • West, Ande3
  • McCarthy, Mary K.4
  • Morrison, Clayton R.5
  • Plante, Kenneth S.6
  • Hampton, Brea K.2
  • Kollmus, Heike7
  • Pilzner, Carolin7
  • Leist, Sarah R.3, 7
  • Gralinski, Lisa E.3
  • Menachery, Vineet D.3, 6
  • Schäfer, Alexandra3
  • Miller, Darla2
  • Shaw, Ginger2
  • Mooney, Michael8, 9
  • McWeeney, Shannon8, 9, 10
  • Pardo-Manuel de Villena, Fernando2, 11
  • Schughart, Klaus7, 12, 13
  • Morrison, Thomas E.4
  • And 3 more
  • 1 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  • 2 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  • 3 Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  • 4 Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA
  • 5 StrideBio, Durham, NC, USA
  • 6 Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
  • 7 Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
  • 8 Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, USA
  • 9 OHSU Knight Cancer Center Institute, Oregon Health and Science University, Portland, OR, USA
  • 10 Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, USA
  • 11 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
  • 12 University of Veterinary Medicine Hannover, Hannover, Germany
  • 13 Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Apr 28, 2020
Volume
31
Issue
4
Pages
107587–107587
Identifiers
DOI: 10.1016/j.celrep.2020.107587
PMID: 32348764
PMCID: PMC7195006
Source
PubMed Central
Keywords
License
Unknown

Abstract

Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.

Report this publication

Statistics

Seen <100 times