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Complex Differential Diagnosis of Cognitive Impairments

Authors
  • Emelin, A. Yu.1
  • Lobzin, V. Yu.1
  • 1 Russian Ministry of Defense, Kirov Military Medical Academy, St. Petersburg, Russia , St. Petersburg (Russia)
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Springer US
Publication Date
Apr 26, 2019
Volume
49
Issue
4
Pages
422–428
Identifiers
DOI: 10.1007/s11055-019-00749-5
Source
Springer Nature
Keywords
License
Yellow

Abstract

This article addresses different aspects of the predementia stage of cognitive disorders of mainly neurodegenerative genesis. Current views of the pathophysiology of the initial stages of cognitive disorders are considered, along with the potential use of in vivo markers for pathological amyloidosis and neurodegeneration. Use of the concept “initial signs of cognitive disorder” is proposed. An algorithm for the complex early diagnosis of cognitive disorders is suggested, and the possibilities and perspectives for clinical-neuropsychological, laboratory, and neuroimaging investigation methods are discussed. Data on the main diseases linked with impairment to cognitive functions are presented. The perspectives for using new highly informative methods for the early differential diagnosis of Alzheimer’s disease and vascular cognitive dementias are evaluated.

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