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The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.

Authors
  • Herrero, M J
  • Vilches, C
  • de Pablo, R
  • Puente, S
  • Kreisler, M
Type
Published Article
Journal
Tissue antigens
Publication Date
Mar 01, 1997
Volume
49
Issue
3 Pt 1
Pages
267–270
Identifiers
PMID: 9098935
Source
Medline
License
Unknown

Abstract

Genotyping of the HLA-C locus by PCR-SSP has previously shown 100% association of B41 and B42 with a new allelic variant. Partial sequencing studies (exons 2-4) demonstrated that this PCR-SSP variant corresponded to the new allele Cw*1701. In this study we have characterized the whole coding region of Cw*1701 from a Bubi individual of Equatorial Guinea. Our results partially confirm the previously reported sequence and reveal that Cw*1701 has many new polymorphisms at several exons, including a 18-bp insertion in exon 5. Cw*1701 is thus a most unusual HLA-C molecule defining a third allelic lineage of this locus.

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