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Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA.

Authors
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
1098-6596
Publisher
American Society for Microbiology
Publication Date
Volume
54
Issue
9
Pages
3967–3969
Identifiers
DOI: 10.1128/AAC.00137-10
PMID: 20547789
Source
Medline
License
Unknown

Abstract

The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.

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