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Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man.

Authors
  • Longepied, Guy
  • Saut, Noemie
  • Aknin-Seifer, Isabelle
  • Levy, Rachel
  • Frances, Anne-Marie
  • Metzler-Guillemain, Catherine
  • Guichaoua, Marie-Roberte
  • Mitchell, Michael J
Type
Published Article
Journal
Human Reproduction
Publisher
Oxford University Press
Publication Date
Oct 01, 2010
Volume
25
Issue
10
Pages
2655–2663
Identifiers
DOI: 10.1093/humrep/deq209
PMID: 20716563
Source
Medline
License
Unknown

Abstract

Our results indicate that the post-meiotic spermatogenesis in 13-1217 is not a consequence of mosaicism or retention of a key AZFb gene. On the contrary, since the Hg-L Y chromosome carried by 13-1217 is uncommon in Western Europe, a Y-linked modifier locus remains a possible explanation for the oligozoospermia observed in patient 13-1217. Further cases must now be studied to understand how germ cells complete spermatogenesis in the absence of the AZFb interval.

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