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Complement-mediated killing of susceptible gram-negative bacteria: an elusive mechanism.

Authors
  • Taylor, P W
Type
Published Article
Journal
Experimental and clinical immunogenetics
Publication Date
Jan 01, 1992
Volume
9
Issue
1
Pages
48–56
Identifiers
PMID: 1642903
Source
Medline
License
Unknown

Abstract

Exposure of gram-negative bacteria to a source of antibody and complement frequently results in efficient cell killing; this effect follows the deposition of C5b-9 membrane attack complexes onto the bacterial surface. This review examines the molecular and physiological events culminating in C5b-9 deposition and cell death and advances an hypothesis that may account for cytoplasmic-membrane damage following complement-mediated perturbation of the outer membrane.

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