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Complement functional tests for monitoring eculizumab treatment in patients with atypical hemolytic uremic syndrome: an update.

Authors
  • Ardissino, Gianluigi1
  • Tel, Francesca2
  • Sgarbanti, Martina3
  • Cresseri, Donata4
  • Giussani, Antenore5
  • Griffini, Samantha6
  • Grovetto, Elena6
  • Possenti, Ilaria2
  • Perrone, Michela2
  • Testa, Sara3
  • Paglialonga, Fabio3
  • Messa, Piergiorgio4
  • Cugno, Massimo6
  • 1 Center for HUS Prevention, Control and Management at the Pediatric and Dialysis Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, v. Commenda, 9, 20122, Milan, Italy. [email protected] , (Italy)
  • 2 Center for HUS Prevention, Control and Management at the Pediatric and Dialysis Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, v. Commenda, 9, 20122, Milan, Italy. , (Italy)
  • 3 Center for HUS Prevention, Control and Management at the Molecular Biology Laboratory, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. , (Italy)
  • 4 Center for HUS Prevention, Control and Management at the Nephrology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. , (Italy)
  • 5 Center for HUS Prevention, Control and Management at the Kidney Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. , (Italy)
  • 6 Center for HUS Prevention, Control, and Management at Medicina Interna, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy. , (Italy)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Mar 01, 2018
Volume
33
Issue
3
Pages
457–461
Identifiers
DOI: 10.1007/s00467-017-3813-2
PMID: 29046944
Source
Medline
Keywords
License
Unknown

Abstract

Monitoring complement activity allows a safe reduction in the frequency of ECU administration in aHUS while keeping the disease in remission.

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