[Complement activation during extracorporeal circulation. A model for understanding lesional pulmonary edema].
- Authors
- Type
- Published Article
- Journal
- La Revue de Médecine Interne
- Publisher
- Elsevier
- Publication Date
- Mar 01, 1984
- Volume
- 5
- Issue
- 1
- Pages
- 21–27
- Identifiers
- PMID: 6718835
- Source
- Medline
- License
- Unknown
Abstract
The complement system (CH50, C3, C4, C3 PA) was monitored during extra-corporeal circulation in 10 patients with ischemic-heart disease. Mean concentrations of CH50, C3, C4, and C3 PA significantly decreased as early as 5 minutes after initiation of the extra-corporeal circulation and decrement remain steady all over the surgical procedure. Transient neutropenia occurred early during the procedure. A significant hypoxemia was present only 24 hours after surgery. We suggest that a complement mediated leukostasis might occur with sequestration in the lungs and contribute to endothelial cell damage with pulmonary edema known as the "post-pump syndrome".