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[Complement activation during extracorporeal circulation. A model for understanding lesional pulmonary edema].

Authors
Type
Published Article
Journal
La Revue de Médecine Interne
0248-8663
Publisher
Elsevier
Publication Date
Volume
5
Issue
1
Pages
21–27
Identifiers
PMID: 6718835
Source
Medline
License
Unknown

Abstract

The complement system (CH50, C3, C4, C3 PA) was monitored during extra-corporeal circulation in 10 patients with ischemic-heart disease. Mean concentrations of CH50, C3, C4, and C3 PA significantly decreased as early as 5 minutes after initiation of the extra-corporeal circulation and decrement remain steady all over the surgical procedure. Transient neutropenia occurred early during the procedure. A significant hypoxemia was present only 24 hours after surgery. We suggest that a complement mediated leukostasis might occur with sequestration in the lungs and contribute to endothelial cell damage with pulmonary edema known as the "post-pump syndrome".

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