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Compatibility of different polymers for cord blood-derived hematopoietic progenitor cells.

Authors
Type
Published Article
Journal
Journal of Materials Science Materials in Medicine
1573-4838
Publisher
Springer-Verlag
Publication Date
Volume
23
Issue
1
Pages
109–116
Identifiers
DOI: 10.1007/s10856-011-4483-4
PMID: 22071984
Source
Medline

Abstract

The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility.

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