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Comparison of tobramycin pharmacokinetics after administration by CRIS and a traditional intravenous piggyback infusion.

Authors
  • Mauro, V F
  • Jacobs, L R
  • Mauro, L S
  • MacArthur, R D
  • White, D B
Type
Published Article
Journal
The Annals of pharmacotherapy
Publication Date
May 01, 1995
Volume
29
Issue
5
Pages
465–469
Identifiers
PMID: 7655128
Source
Medline
License
Unknown

Abstract

CRIS administration of tobramycin resulted in higher AUCs than did ivpb administration. Compared with ivpb, fast CRIS resulted in a higher Cmax, but the tmax values of fast CRIS and ivpb administration were not statistically different. Compared with ivpb, slow CRIS resulted in a more delayed tmax, but the Cmax values of slow CRIS and ivpb were not statistically different.

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