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Comparison of Radiochemical and Chemical Impurities in Liquid Wastes of Two Different 68Ge/ 68Ga Generators used in Nuclear Medicine PET Chemistry

  • Uğur, Ayşe1
  • Yaylalı, Olga2
  • Yüksel, Doğangün2
  • 1 Pamukkale University Training and Research Hospital, Clinic of Nuclear Medicine, Denizli, Turkey
  • 2 Pamukkale University Faculty of Medicine, Department of Nuclear Medicine, Denizli, Turkey
Published Article
Molecular Imaging and Radionuclide Therapy
Galenos Publishing
Publication Date
Feb 09, 2021
DOI: 10.4274/mirt.galenos.2020.58569
PMID: 33586405
PMCID: PMC7885278
PubMed Central
  • Original Article


Objectives: Germanium-68/gallium-68 (68Ge/68Ga) generator eluate contains a number of metal cations that can compete with 68GaCl3, reducing specific radioactivity. The first step in peptide labeling with 68GaCl3 is to remove 68Ge and several other metals with a long half-life. In this purification step, the elution residue that is passed through the cartridge is collected in glass waste bottles. Waste management is included in good production practices, and in particular, the activity of long half-life 68Ge (270.95 days) and other toxic metal levels need to be examined. Our objective in this study is to determine the 68Ge activity in liquid waste produced by the generation of 68Ga and heavy metal concentrations from the generator column materials and to assess whether it can be disposed of as normal waste. Methods: Liquid wastes produced by passing the 68Ge/68Ga generator eluate of 2 different identities via PSH+ cartridge have been analyzed with the inductively coupled plasma mass spectrometry device in the advanced technology application and research center of our university. Results: The average of the 68Ge radioactive pollution was estimated to be 0.142 ppm (μg.mL-1) in the liquid waste analysis after passing through the PSH+ cartridge in the pre-elution in the GalluGEN brand generator. While there was no tin (Sn) impurity, it was determined that the average zinc (Zn) was 1.95 ppm (μg.mL-1) and the average aluminum (Al) impurity was 10.95 ppm (μg.mL-1). While no 68Ge radioactive pollution was determined in the iThemba LABS brand generator, the average Sn was 0.098 ppm (μg.mL-1), average Zn 48.6 ppm (μg.mL-1), and average Al impurity 4.135 ppm (μg.mL-1). Conclusion: All 68Ge/68Ga generators produced have their own certificates. Metallic contamination in the postmarking waste of 68Ge/68Ga generators can be different. It would be a safe method to keep these wastes in place until they are dumped into the sewage systems, given their half-lives in terms of long half-life radioactive metallic contamination.

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