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Comparison of the pharmacokinetics of two dosage regimens of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients.

Authors
  • Alffenaar, Jan-Willem C
  • van Altena, Richard
  • Harmelink, Ilse M
  • Filguera, Patricia
  • Molenaar, Esther
  • Wessels, A Mireille A
  • van Soolingen, Dick
  • Kosterink, Jos G W
  • Uges, Donald R A
  • van der Werf, Tjip S
Type
Published Article
Journal
Clinical pharmacokinetics
Publication Date
Aug 01, 2010
Volume
49
Issue
8
Pages
559–565
Identifiers
DOI: 10.2165/11532080-000000000-00000
PMID: 20608757
Source
Medline
License
Unknown

Abstract

Seemingly effective serum concentrations were reached after 3 days of administration of linezolid 300 mg twice daily, i.e. the AUC(24)/MIC ratio was at least 100 in 7 of 8 patients. Larger numbers of patients should be studied to confirm the efficacy of the linezolid 300 mg twice-daily dosage in MDR-TB or XDR-TB treatment.

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