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Comparison of the pharmacokinetics of two dosage regimens of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients.

Authors
Type
Published Article
Journal
Clinical pharmacokinetics
Publication Date
Volume
49
Issue
8
Pages
559–565
Identifiers
DOI: 10.2165/11532080-000000000-00000
PMID: 20608757
Source
Medline
License
Unknown

Abstract

Seemingly effective serum concentrations were reached after 3 days of administration of linezolid 300 mg twice daily, i.e. the AUC(24)/MIC ratio was at least 100 in 7 of 8 patients. Larger numbers of patients should be studied to confirm the efficacy of the linezolid 300 mg twice-daily dosage in MDR-TB or XDR-TB treatment.

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