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A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50, and human insulin: a randomized, quadruple crossover study.

Authors
  • Ma, Zhulin1
  • Parkner, Tina
  • Frystyk, Jan
  • Laursen, Torben
  • Lauritzen, Torsten
  • Christiansen, Jens Sandahl
  • 1 Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark. [email protected] , (Denmark)
Type
Published Article
Journal
Diabetes Technology & Therapeutics
Publisher
Mary Ann Liebert
Publication Date
Jul 01, 2012
Volume
14
Issue
7
Pages
589–595
Identifiers
DOI: 10.1089/dia.2011.0299
PMID: 22519735
Source
Medline
License
Unknown

Abstract

BIAsp70 and BIAsp50 injected immediately before a meal are at least as effective as human insulin injected 30 min earlier in controlling postprandial glycemic excursions. BIAsp50 showed the greatest similarity to human insulin with regard to pharmacokinetic and pharmacodynamic profiles.

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