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Comparison of NaF and FDG PET/CT for assessment of treatment response in castration-resistant prostate cancers with osseous metastases.

Authors
  • Simoncic, Urban1
  • Perlman, Scott2
  • Liu, Glenn3
  • Staab, Mary Jane4
  • Straus, Jane Elizabeth4
  • Jeraj, Robert5
  • 1 Jozef Stefan Institute, Ljubljana, Slovenia; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI; Centre of Excellence for Biosensors, Instrumentation and Process Control (COBIK), Ajdovscina, Slovenia. Electronic address: [email protected] , (Slovenia)
  • 2 Department of Radiology, University of Wisconsin-Madison, Madison, WI; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
  • 3 Genitourinary Oncology Research Program, University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
  • 4 University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
  • 5 Jozef Stefan Institute, Ljubljana, Slovenia; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI; Department of Radiology, University of Wisconsin-Madison, Madison, WI; Centre of Excellence for Biosensors, Instrumentation and Process Control (COBIK), Ajdovscina, Slovenia; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI. , (Slovenia)
Type
Published Article
Journal
Clinical Genitourinary Cancer
Publisher
Elsevier
Publication Date
February 2015
Volume
13
Issue
1
Identifiers
DOI: 10.1016/j.clgc.2014.07.001
PMID: 25128349
Source
Medline
Keywords
License
Unknown

Abstract

This study found that late NaF and FDG uptake responses are consistently correlated but that earlier uptake responses and all vasculature responses can be unrelated. This study also confirmed that FDG and NaF uptakes are spatially dislocated. Although treatment responses assessed with NaF and FDG may be correlated, using both tracers provides additional information.

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