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Comparison of labial minor salivary gland biopsies from childhood Sjögren syndrome and age-matched controls.

Authors
  • Yokogawa, Naoto1
  • Lieberman, Scott M2
  • Alawi, Faizan1
  • Bout-Tabaku, Sharon1
  • Guttenberg, Marta1
  • Sherry, David D1
  • Vivino, Frederick B1
  • 1 From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. , (Japan)
  • 2 From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. [email protected] , (Japan)
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Jun 01, 2014
Volume
41
Issue
6
Pages
1178–1182
Identifiers
DOI: 10.3899/jrheum.131511
PMID: 24786923
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS). Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist. The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples. The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

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