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Comparison of Japanese isolates of Coxiella burnetii by PCR-RFLP and sequence analysis.

Authors
  • Andoh, Masako
  • Nagaoka, Hiromi
  • Yamaguchi, Tsuyoshi
  • Fukushi, Hideto
  • Hirai, Katsuya
Type
Published Article
Journal
Microbiology and immunology
Publication Date
Jan 01, 2004
Volume
48
Issue
12
Pages
971–975
Identifiers
PMID: 15611614
Source
Medline
License
Unknown

Abstract

The genetic variation of Japanese isolates of Coxiella burnetii, the agent of Q fever, was found for the first time. Forty-nine out of 72 isolates had the chronic pattern of the isocitrate hydrogenase gene. Sequence analysis revealed that the isolates have a specific nucleotide sequence. The putative amino acid sequence was the same as that of chronic reference strains. These results suggest the variation of C. burnetii isolates in Japan.

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