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A comparison of inflammatory markers in manic and euthymic states of bipolar disorder.

Authors
  • Özdin, Selçuk1
  • Usta, Miraç Barış2
  • 1 Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey. , (Turkey)
  • 2 Child and Adolescent Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey. , (Turkey)
Type
Published Article
Journal
Nordic Journal of Psychiatry
Publisher
Informa UK (Taylor & Francis)
Publication Date
Aug 17, 2020
Pages
1–6
Identifiers
DOI: 10.1080/08039488.2020.1807048
PMID: 32804583
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The number of studies investigating inflammatory biomarkers in bipolar disorder has increased significantly in recent years. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) are inexpensive and easy to obtain values used to measure the level of inflammation. This study compared the NLR, PLR, and MLR values in the manic and euthymic phases of the same patients. Patients who met the inclusion criteria and were hospitalized due to bipolar affective disorder manic episodes at the Ondokuz Mayis University Faculty of Medicine inpatient psychiatry clinic between 01.01.2013 and 01.01.2019 were enrolled in the study. One hundred thirteen patients undergoing manic episodes were included. White blood cells, neutrophil, lymphocyte, platelet, and monocyte counts were retrospectively recorded from complete blood count data collected during the hospital stay, and NLR, PLR, and MLR values were calculated from these. Neutrophil, platelet, and monocyte counts, as well as NLR, PLR, and MLR values were higher in the manic episodes of bipolar disorder compared to the control group. Decreased neutrophil and lymphocyte counts, and decreased NLR, PLR, and MLR were observed in the remission period after-treatment of the manic bipolar disorder episodes. In the euthymic phase of bipolar disorder, however, platelet and monocyte counts and MLR were higher than in the control group. The study indicates that NLR and PLR may be used as state markers and that MLR may be used as a trait marker in bipolar disorder.

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