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Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism

  • Wang, Wenqiang1
  • He, Jia1
  • Hu, Yunhua1
  • Song, Yanpeng2
  • Zhang, Xianghui1
  • Guo, Heng1
  • Wang, Xinping1
  • Keerman, Mulatibieke1
  • Ma, Jiaolong1
  • Yan, Yizhong1
  • Zhang, Jingyu1
  • Ma, Rulin1
  • Guo, Shuxia1, 3
  • 1 Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang
  • 2 Department of Social Work, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang
  • 3 Department of NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang
Published Article
Diabetes Metabolic Syndrome and Obesity Targets and Therapy
Dove Medical Press
Publication Date
Oct 01, 2021
DOI: 10.2147/DMSO.S330212
PMCID: PMC8491784
PubMed Central
  • Original Research


Background We aimed to identify the relationship between metabolically healthy obesity (MHO), a special subtype of obesity, and the incidence of cardiovascular disease (CVD) in rural Xinjiang. Methods Body mass index (BMI) and the Joint Interim Statement criteria were utilized to define obesity and metabolic status, respectively. A baseline survey was conducted between 2010 and 2012. The cohort was followed-up until 2017, including 5059 participants (2953 Uyghurs and 2106 Kazakhs) in the analysis. Results During 6.78 years of follow-up, 471 individuals developed CVD, 10.8% (n=545) of whom were obese, and the prevalence of MHO and MHNW was 5.2% and 54.5%, respectively. Compared with metabolically healthy normal weight subjects, the subjects with MHO had an increased risk of CVD (hazard ratio [HR]=1.76, 95% confidence interval [CI]: 1.23−2.51), while the metabolically unhealthy obesity (MUO) group had an even higher risk (HR=3.80, 95% CI: 2.87−5.03). Additionally, there were sex differences in the relationship between BMI-metabolic status and incident CVD ( P interaction =0.027). Compared with the subjects with MHO, those with MUO had an increased risk of CVD (HR=1.84, 95% CI: 1.26−2.71). Conclusion MHO was associated with a high risk of CVD among adults in rural Xinjiang. In each BMI category, metabolically unhealthy subjects had a higher risk of developing CVD than did metabolically healthy subjects.

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