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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.

Authors
  • Boursier, Jérôme
  • de Ledinghen, Victor
  • Zarski, Jean-Pierre
  • Fouchard-Hubert, Isabelle
  • Gallois, Yves
  • Oberti, Frédéric
  • Calès, Paul
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2012
Volume
55
Issue
1
Pages
58–67
Identifiers
DOI: 10.1002/hep.24654
PMID: 21898504
Source
Medline
License
Unknown

Abstract

SAFE and BA for significant fibrosis or cirrhosis are very accurate. However, their successive use induces a significant decrease in diagnostic accuracy and a significant increase in required liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests was as accurate as successive SAFE or BA, while providing an entirely noninvasive (0% liver biopsy) and more precise (six versus two or three fibrosis classes) fibrosis diagnosis.

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