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Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.

Authors
  • Kamiya, Y
  • Andoh, T
  • Furuya, R
  • Hattori, S
  • Watanabe, I
  • Sasaki, T
  • Ito, H
  • Okumura, F
Type
Published Article
Journal
Anesthesiology
Publication Date
Jun 01, 1999
Volume
90
Issue
6
Pages
1704–1713
Identifiers
PMID: 10360870
Source
Medline
License
Unknown

Abstract

Both convulsant and depressant stereoisomers of the barbiturate inhibited the AMPA receptor-mediated current despite of their opposite effects on the central nervous system in vivo. Although thiopental exhibited a considerable inhibition of AMPA receptors, the results suggest that the inhibition of AMPA receptors contributes little to the hypnotic action of the barbiturates.

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