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A comparison of a divided and a single dose regime of dothiepin and its therapeutic efficacy.

Authors
  • Sharma, S D
Type
Published Article
Journal
Indian Journal of Psychiatry
Publisher
Medknow Publications
Publication Date
Oct 01, 1981
Volume
23
Issue
4
Pages
355–359
Identifiers
PMID: 22058563
Source
Medline
License
Unknown

Abstract

In a double-blind study the advantages of a once-a-day dosage of a tricyclic antidepressant as against a thrice daily dosage regimen was evaluated using dothiepin (Prothiaden) and matching placebo tablets. Twenty eight adult patients of both sexes participated in the study and were randomly allocated to drug treatment. Out of 28 patients who received dothiepin, 17 showed good improvement, in 6 improvement was fair and in 5 there was no improvement. These findings show that the response to dotheipin was satisfactory. Further, both treatments were equally effective in relieving symptoms of depression.

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