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Comparison of Diskus inhaler, a new multidose powder inhaler, with Diskhaler inhaler for the delivery of salmeterol to asthmatic patients. Canadian Study Group.

Authors
  • Boulet, L P1
  • Cowie, R
  • Johnston, P
  • Krakovsky, D
  • Mark, S
  • 1 Hôpital Laval, Sainte-Foy, Quebec, Canada.
Type
Published Article
Journal
The Journal of asthma : official journal of the Association for the Care of Asthma
Publication Date
1995
Volume
32
Issue
6
Pages
429–436
Identifiers
PMID: 7592246
Source
Medline
License
Unknown

Abstract

Administration of the long-acting beta 2-adrenoceptor agonist salmeterol from a new, easy-to-operate, multidose powder inhaler (Diskus) containing 60 sealed doses in a foil strip has been compared with administration from a Diskhaler inhaler in a multicenter, double-blind, double-dummy, parallel-group study. Asthmatic patients taking anti-inflammatory treatment, with baseline FEV1 > or = 60% and < or = 90% predicted were treated for 4 weeks with salmeterol 50 micrograms twice daily from either the Diskus or Diskhaler inhaler. The two treatments were equivalent (90% CLs for the difference in mean morning PEFR: -2.2, 8.7 L/min). The Diskus inhaler was rated easier to use and was preferred by more patients than the Diskhaler inhaler (73% vs. 15%).

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