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Comparison of different types of blood pool agents (P792, MS325, USPIO) in a rabbit MR angiography-like protocol.

Authors
  • Corot, Claire
  • Violas, Xavier
  • Robert, Philippe
  • Gagneur, Georgia
  • Port, Marc
Type
Published Article
Journal
Investigative Radiology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 01, 2003
Volume
38
Issue
6
Pages
311–319
Identifiers
PMID: 12908698
Source
Medline
License
Unknown

Abstract

The BPA P792 and USPIO have favorable properties that result from their intravascular retention and their lack of extravasation, allowing optimal contrast between the vessel and the adjacent tissue for several minutes postinjection. Combining a rapid body clearance and a marked T1 effect, P792 presents optimal blood pool characteristics for angiographic applications. During the bolus phase, MS-325 is mainly in free form, which presents the disadvantage of increasing the tissue signal background, due to extravasation of the free form.

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