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Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.

Authors
Type
Published Article
Journal
Toxicology
0300-483X
Publisher
Elsevier
Publication Date
Volume
211
Issue
1-2
Pages
12–25
Identifiers
PMID: 15863244
Source
Medline
License
Unknown

Abstract

Both selective and non-selective COX-2 inhibitors were toxic for rats fetuses when administered in the highest dose. Unlike DFU, piroxicam was also highly toxic to the dams. Prenatal exposure to selective COX-2 inhibitors does not increase the risk of ventricular septal and midline defects in rat when compared to non-selective drugs and historic control.

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