Affordable Access

Access to the full text

Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques

  • Yamaki, Takahiko1
  • Kawasaki, Masanori1
  • Jang, Ik-Kyung2
  • Raffel, Owen Christopher2
  • Ishihara, Yoshiyuki1
  • Okubo, Munenori1
  • Kubota, Tomoki1
  • Hattori, Arihiro1
  • Nishigaki, Kazuhiko1
  • Takemura, Genzou1
  • Fujiwara, Hisayoshi1
  • Minatoguchi, Shinya1
  • 1 Gifu University Graduate School of Medicine, Department of Cardiology, 1-1 Yanagido, Gifu, 501-1194, Japan , Gifu (Japan)
  • 2 Massachusetts General Hospital and Harvard Medical School, Cardiology Division, Boston, MA, USA , Boston (United States)
Published Article
Cardiovascular Ultrasound
Springer (Biomed Central Ltd.)
Publication Date
Aug 06, 2012
DOI: 10.1186/1476-7120-10-33
Springer Nature


BackgroundThe purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT).MethodsCoronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components.ResultsPlaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059).ConclusionLipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.

Report this publication


Seen <100 times