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Comparison between Hyper-CVAD and PETHEMA ALL-93 in Adult Acute Lymphoblastic Leukemia: A Single-Center Study.

Authors
  • Erkut, Nergiz1
  • Akidan, Osman2
  • Selim Batur, Derya3
  • Karabacak, Volkan4
  • Sonmez, Mehmet3
  • 1 Department of Hematology, School of Medicine, Karadeniz Technical University, Trabzon, [email protected] , (Turkey)
  • 2 Department of Internal Medicine, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. , (Turkey)
  • 3 Department of Hematology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. , (Turkey)
  • 4 Department of Public Health, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. , (Turkey)
Type
Published Article
Journal
Chemotherapy
Publisher
S. Karger AG
Publication Date
Jan 01, 2018
Volume
63
Issue
4
Pages
207–213
Identifiers
DOI: 10.1159/000492531
PMID: 30304722
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although cure rates in pediatric acute lymphoblastic leukemia (ALL) are quite high with combined chemotherapy regimens, complete response (CR) and long-term survival rates in adults are 80-90 and 30-40%, respectively. Currently, combined chemotherapy regimens, such as Hyper-CVAD and PETHEMA, are used in patients with adult ALL. However, there has been no study comparing the results of Hyper-CVAD and PETHEMA ALL-93. In this retrospective single-center study, we evaluated the results of Hyper-CVAD and PETHEMA ALL-93 in 51 ALL patients treated between September 2008 and March 2017 at the Department of Hematology, Faculty of Medicine, Karadeniz Technical University. Thirty-eight patients were treated with Hyper-CVAD and 13 with PETHEMA ALL-93. CR was obtained in 90 and 100% of patients, respectively. Survival estimates were comparable between Hyper-CVAD and PE-THEMA ALL-93, with a median overall survival (OS) and a median disease-free survival (DFS) of 17.5 and 12.1 months, respectively, for Hyper-CVAD and of 18.6 and 12.9 months, respectively, for PETHEMA ALL-93. The 2-year OS rates for Hyper-CVAD and PETHEMA ALL-93 were 30 and 40%, respectively, and the 2-year DFS rates were 28 and 44%, respectively. PETHEMA ALL-93 resulted in more hepatotoxicity, hypofibrinogenemia, aspergillus infection, and skin rash than Hyper-CVAD. Although Hyper-CVAD and PE-THEMA ALL-93 showed similar effects, Hyper-CVAD was tolerated better. Age and comorbidities should be taken into account before a chemotherapy regimen is determined for patients with ALL. © 2018 S. Karger AG, Basel.

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