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Comparison among different presentations of venous thromboembolism because of lung cancer.

Authors
  • Guo, Jian1, 2
  • Deng, Qin-Fang1, 3
  • Xiong, Wei2, 4
  • Pudasaini, Bigyan2
  • Yuan, Ping2
  • Liu, Jin-Ming2
  • Zhou, Cai-Cun1, 3
  • 1 Soochow University, Suzhou, China. , (China)
  • 2 Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. , (China)
  • 3 Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. , (China)
  • 4 Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. , (China)
Type
Published Article
Journal
The Clinical Respiratory Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2019
Volume
13
Issue
9
Pages
574–582
Identifiers
DOI: 10.1111/crj.13060
PMID: 31306554
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Venous thromboembolism (VTE) because of lung cancer has been sufficiently studied, nevertheless, little is known regarding the discrepancy of clinical characteristics and predictive factors among different presentations of VTE because of lung cancer. This study was designed to investigate the distinction of clinical characteristics and predictive factors among different presentations of VTE because of lung cancer. All patients concomitant lung cancer and VTE were stratified into three groups: pulmonary embolism (PE) group in which patients had sole PE, deep vein thrombosis (DVT) group with sole DVT and concomitance group with both PE and DVT. Concomitance of PE and DVT (28.2 days) mostly occurred at the early stage after the diagnosis of lung cancer, by contrast with DVT (63.6 days) which did at the latest stage, whereas PE (36.7 days) generally developed intermediately in between (P = .02). In a Kaplan-Meier analysis, the cumulative survival rate of DVT group was higher than that of concomitance group, whereas the rate of PE group lied in between. (P = .002) The strongest correlated factors with the development of DVT, PE and concomitance were adenocarcinoma (HR 3.27, P = .003), chemotherapy (HR 2.62, P = .005) and D-Dimer (HR 3.88, P < .001), respectively. The strongest correlated factors with the mortality of DVT, PE and concomitance were comorbidity (HR 2.32, P = .003), metastasis (HR 3.12, P < .001), and metastasis (HR 4.29, P < .001), respectively. Concomitance of DVT and PE represents the severest state of lung cancer, the earliest occurrence of VTE, and the worst survival rate, whereas DVT stands for the mildest condition of lung cancer and stablest pattern of VTE. © 2019 John Wiley & Sons Ltd.

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