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Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study

Authors
  • Zhou, Yu1
  • Du, Ling2
  • Tu, Bo3
  • Lai, Qiquan1
  • Du, Xiaonan2
  • Xu, Bo4
  • Zhang, Fan5
  • Zhao, Mingdong6
  • Wan, Ziming1
  • Lai, Jiajie7
  • 1 The First Affiliated Hospital of Chongqing Medical University, Department of Nephrology, Youyi Road No.1, Yuzhong District, Chongqing, 400016, China , Chongqing (China)
  • 2 Tongji Medical College, Huazhong University of Science and Technology, Department of Anesthesiology, The Central Hospital of Wuhan, Gusao Road No. 16, Jianghan District, Wuhan, Hubei, 430014, China , Wuhan (China)
  • 3 The First Affiliated Hospital of Chongqing Medical University, Department of Ultrasonography, Youyi Road No.1, Yuzhong District, Chongqing, 400016, China , Chongqing (China)
  • 4 The First Affiliated Hospital of Sun Yat-sen University, Department of Thoracic surgery, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China , Guangzhou (China)
  • 5 The First Affiliated Hospital of Sun Yat-sen University, Radiology Department, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China , Guangzhou (China)
  • 6 Jinshan Hospital, Fudan University, Department of Orthopaedics, Longhang Road No. 1508, Jinshan District, Shanghai, 201508, China , Shanghai (China)
  • 7 The First Affiliated Hospital of Sun Yat-sen University, Department of Gynaecology and obstetrics, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China , Guangzhou (China)
Type
Published Article
Journal
BMC Nephrology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Dec 27, 2018
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12882-018-1166-0
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundTo assess the time to first on-study vascular thromboembolic events (VTEs) of clopidogrel (CL) or beraprost sodium (BPS) in Chinese population with end-stage renal disease (ESRD) treated with arteriovenous fistula (AVF) surgery.MethodsFrom Jan 2009 to May 2015, 346 ESRD cases suffering an AVF surgery and undergoing oral administration of 75 mg CL (initial dose of 300 mg), 1 time/day, for 4 weeks or 40 μg BPS, 3 times/day, for 4 weeks were retrospectively assessed. The primary outcome was time to first on-study VTE.ResultsIn total, 222 ESRD cases (CL, n = 112; BPS, n = 110) were assessed, with a median follow-up time of 38.1 months (range, 37–40 months). The mean time to first on-study VTE was 1.2 weeks (0.5–2.3) and 1.8 weeks (1.2–3.8) for CL and BPS, respectively (HR 0.27, 95% CI 0.16–1.45; P = 0.00). An increased incidence of VTEs was found during the 1th-month follow-up, with rates of 14.2 and 5.5% for CL and BPS, respectively (P = 0.03). The difference persisted over time, with rates of 24.1 and 11.8% at final follow-up, respectively (P = 0.02).ConclusionCL with an increased risk of VTEs tended to have a VTE within the 1st month after cessation compared with BPS.

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