Affordable Access

Publisher Website

Comparative in vitro cytotoxicity toward human osteoprogenitor cells of polycaprolactones synthesized from various metallic initiators.

Authors
Type
Published Article
Journal
Macromolecular bioscience
Publication Date
Volume
10
Issue
1
Pages
60–67
Identifiers
DOI: 10.1002/mabi.200900184
PMID: 19890951
Source
Medline

Abstract

Various poly(epsilon-caprolactone)s (PCLs) prepared by ring-opening polymerization of epsilon-caprolactone (CL) initiated by a range of metallic derivatives such as alkoxides, Al(OiPr)(3), La(OiPr)(3), Sn(octanoate)(2), Ti(OiPr)(4), Zn[O(CH(2))(3)NH(t)Boc](2), or borohydride La(BH(4))(3)(THF)(3) were evaluated for their in vitro cytotoxicity. The amount of residual metal present in the polymer samples was measured and compared to the initial quantity introduced. The effect of the metallic system on the biocompatibility profiles of the resulting polyesters was evaluated in vitro on PCL films from a series of cytotoxicity tests involving MTT and neutral red assays upon exposure to human osteoprogenitor cells. The absence of toxic influence of all these PCLs suggests that they may be used as biomaterials in contact with living human cells.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F