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Comparative study of the swabbing properties of seven commercially available swab materials for cleaning verification.

Authors
  • Corrigan, Damion K
  • Piletsky, Sergey
  • McCrossen, Sean
Type
Published Article
Journal
PDA journal of pharmaceutical science and technology / PDA
Publication Date
Jan 01, 2009
Volume
63
Issue
2
Pages
184–193
Identifiers
PMID: 19634356
Source
Medline
License
Unknown

Abstract

This article compares the technical performances of several different commercially available swabbing materials for the purpose of cleaning verification. A steel surface was soiled with solutions of acetaminophen, nicotinic acid, diclofenac, and benzamidine and wiped with each swabbing material. The compounds were extracted with water or ethanol (depending on polarity of analyte) and their concentration in extract was quantified spectrophotometrically. The study also investigated swab debris on the wiped surface. The swab performances were compared and the best swab material was identified.

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