[Comparative study of the fate of fluorofur and 5-fluorouracil in the organism].
- Published Article
- Publication Date
Jan 01, 1975
Fluorofur (FT) is slowly splitted in tissues releasing free 5-FU. The duration of stay in the organism of 5-FU formed from FT is longer than that of 5-FU administered solely. Moreover, FT does not result in the formation of such high 5-FU concentrations, as observed while using 5-FU itself. It seems to account for an insignificant toxicity of FT and its greater efficacy in treatment of malignant tumors.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1189367