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Comparative study of the enantioselective separation of several antiulcer drugs by high-performance liquid chromatography and supercritical fluid chromatography.

Authors
  • Toribio, L
  • del Nozal, M J
  • Bernal, J L
  • Alonso, C
  • Jiménez, J J
Type
Published Article
Journal
Journal of Chromatography A
Publisher
Elsevier
Publication Date
Oct 14, 2005
Volume
1091
Issue
1-2
Pages
118–123
Identifiers
PMID: 16395800
Source
Medline
License
Unknown

Abstract

A comparative study of the enantiomeric separation of several antiulcer drugs such as omeprazole, lansoprazole, rabeprazole and pantoprazole using HPLC and supercritical fluid chromatography (SFC) on the Chrialpak AD column is presented in this work. The results show that employing the above mentioned column only two compounds (omeprazole and pantoprazole) could be enantiomerically resolved using HPLC, on the contrary SFC allowed the enantiomeric separation of all the compounds studied with higher resolutions and lower analysis times.

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