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A comparative study of the effect of some steroid hormones on the response of rats to other drugs.

Authors
  • Ghazal, A
  • Makar, A B
  • Islam, S I
Type
Published Article
Journal
Die Pharmazie
Publication Date
Sep 01, 1975
Volume
30
Issue
9
Pages
606–608
Identifiers
PMID: 127182
Source
Medline
License
Unknown

Abstract

The effect of a series of steroid hormones on the pentetrazol convulsing action, hexobarbital narcotic action and hepatic drug metabolizing enzyme activities was determined in rats. All steroid compounds used antagonized the pentetrazol effect: the most potent was cortisone and the least potent testosterone. Glucocorticoids and androgens shortened the hexobarbital sleeping time and increased the hepatic drug metabolizing enzyme activity. Estradiol exhibited the opposite effect, whereas progesterone and desoxycorticosterone did not affect these two parameters.

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